Since high expression of NKG2DL can be induced by FLT3 inhibitors, researchers constructed dual-target FLT3scFv/NKG2D CAR-T cells, and examined the inhibitory effects in vitro, which showed the powerful ability to lyse AML cells and improvement by gilteritinib-pretreatment (59). This evidence concerns the gene FLT3 and acute myeloid leukemia.