The consistent improvement in PFS and OS across various demographic and pathological characteristics, including age, sex, ECOG performance status, PD-L1 status, microsatellite status, tumor site, subtype, and history of previous gastrectomy or esophagectomy, suggests that ICI plus CT may benefit a broad spectrum of patients with advanced G/GEJ adenocarcinoma. The gene discussed is CD274; the disease is neoplasm.