To explore the influence of diverse pathological attributes on the therapeutic outcome of ICIs in conjunction with CT for G/GEJ adenocarcinoma, we performed a series of subgroup assessments based on various factors such as PD-L1 status, microsatellite status, tumor site, subtype, history of previous gastrectomy or esophagectomy, and number of metastasis sites. The gene discussed is CD274; the disease is gastroesophageal junction adenocarcinoma.