Since the clinical signs of late hypogonadism and hyposomatotropism significantly overlap, some authors believe that they are the result of a common pathophysiology, i.e. that the decrease in GH/IGF-1 secretion is the result of decreased androgen secretion that decreases with age and decreases hypothalamic-pituitary GH function/IGF-1 axis [32]. Here, IGF1 is linked to hypogonadism.