The results manifested that among HCM patients carrying genotype GG of ACE2 gene polymorphism rs102312, the ratios of NYHA class ≥3, course of chronic heart failure >1 year and hypertension were higher, and they also had a higher level of serum BNP (p<0.05) (Table 7). The gene discussed is ACE2; the disease is congestive heart failure.