DSG1 and acute myeloid leukemia: The overlap of DSG identified in human and mouse cells revealed that approximately 20% of aberrantly spliced genes in KL (mouse) cells were also mis-spliced in MDS/AML (human) cells for both U2AF1S34F (17.6% shared) and U2AF1Q157R (19.7% shared) mutants (Fig. 7F,G).