Finally, mediation analyses revealed 8 biomarkers (i.e., CRP, RBC, RBC distribution width, WBC, platelet, basophil, neutrophil, and nucleated red blood cell percentage) served as mediators in the relationship between CAID-PRS and 5 individual AID-PRSs and the risk of hematological cancer, male genital cancer, and 6 individual cancers, accounting for 0.57–16.96% of these associations (Table 2). This evidence concerns the gene CRP and hematopoietic and lymphoid cell neoplasm.