Mediation analyses revealed immunosuppressant use and 9 biomarkers (i.e., CRP, basophil, high light scatter reticulocyte [HLSR], monocyte, neutrophil, platelet, red blood cell [RBC], RBC distribution width, white blood cell [WBC]) partly mediated the associations of baseline AID with the risk of overall cancer, urinary cancer, digestive cancer, and 3 individual cancers (Table S27). This evidence concerns the gene AICDA and cancer.