We identified a set of inflammatory cytokines, including IL-1alpha, IL-4, IL-6, IL-7, IL-9, IL-15 and TNF-alpha, which are elevated in the serum of JAK2V617F mice (Fig. 2A), similar to the alterations in circulating cytokines observed in patients with myelofibrosis[50]. The gene discussed is TNF; the disease is myelofibrosis.