HDAC11 is the sole member of the class IV HDAC subfamily and the most recently identified HDAC protein.(Gao et al., 2002) It is predominantly expressed in the brain, skeletal muscle, heart, testis, and kidney.(Gao et al., 2002) While previous studies have linked HDAC11 to brain degeneration, chronic muscle metabolic disease, myocarditis, and various tumors,(Chen et al., 2022; Khatun et al., 2024; Liu et al., 2020; Liu et al., 2023) its role in kidney diseases has been less explored. The gene discussed is HDAC11; the disease is kidney disorder.