Inflammation plays a crucial role in renal fibrosis.(Yeh et al., 2024) and HDAC11 was initially identified as a negative regulator of the anti-inflammatory cytokine IL-10.(Lai et al., 2011; Yanginlar and Logie, 2018) To investigate whether inhibition of HDAC11 with FT895 reduces inflammation, we conducted qRT-PCR to analyze mRNA expression of IL-10 and several pro-inflammatory cytokines, including interleukin-1b (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-a (TNF-α). The gene discussed is IL10; the disease is renal fibrosis.