Figures 3G, 3H, and 3I show that there was a nonlinear association (S shaped relation) between LAP, VAI or CMI and risk of MCI in elderly patients with T2D (all P for non-linearity < 0.001). The risk of MCI increased when the level of LAP exceeded 36.11 after adjusting for age, education, hypertension, stroke, anti-diabetic drugs (GLP-1R agonists and SGLT-2 inhibitors) and HbA1c (Fig. 3G). The level of VAI (more than 1.91, Fig. 3H) and CMI (more than 0.65, Fig. 3I) also showed similar nonlinear patterns. This evidence concerns the gene SLC5A2 and stroke disorder.