(5) Emodin has been shown to aid in weight loss; since it is a primary component of Chinese rhubarb, prolonged use may impair gastric qi and affect appetite and digestion, so this raises questions about whether its weight loss and blood glucose-lowering effects are achieved at the expense of appetite and food intake in T2DM animal models or through direct reductions in blood glucose levels and insulin concentrations. This evidence concerns the gene INS and type 2 diabetes mellitus.