PIK3CA and Familial prostate cancer: Subsequently, KEGG pathway analysis revealed that the DE-ARGs were enriched in pathways such as microRNAs in cancer, focal adhesion, proteoglycans in cancer, PI3K-AKT signaling pathway, prostate cancer, cell cycle, RAP1 signaling pathway, adherens junction, EGFR tyrosine kinase inhibitor resistance, and HIF-1 signaling pathway (Figure 2C).