VCAN and neoplasm: Compared with the tumour cells in the control group, the tumour weight/body weight of the nude mice was significantly reduced 14 days after the VCAN knockdown tumour cells were injected subcutaneously into nude mice, and the results showed that the tumour size could be suppressed by VCAN knockdown, suggesting that VCAN is one of the key genes promoting tumour growth (Figure 6A-C).