Tumours overexpressing the G3 structural domain not only had high levels of 4B6, pEGFR, pAKT, and GSK-3β (S9P), all of which are associated with tumour aggressiveness, but also exhibited high levels of the tumour stem cell markers Sox2, Sca-1, and ALDH1 47. This evidence concerns the gene ALDH1A1 and neoplasm.