The expression of tumor differentiation grade-related genes prognostic signature in clusters (TNFAIP2, MAGEA3, CXCR4, COL1A1, FN1, VCAN, PXDN, COL5A1, MUC13 and RGS2) was shown in Fig.1G. Additionally, cell type was annotated for each cell sample, and all the cells in the six clusters were annotated as epithelial cells and macrophage (Figure 1H). This evidence concerns the gene VCAN and neoplasm.