Multivariate Cox proportional hazards regression analysis revealed five independent predictors of MACEs: (1) diabetes (HR: 2.532; 95% CI: 1.179-5.438; P=0.017); (2) nLF/nHF ratio (HR: 0.409; 95% CI: 0.191-0.875; P=0.021); (3) cTnI level (HR: 1.065; 95% CI: 1.006-1.128; P=0.031); (4) post-PCI QFR of target vessel (HR: 0.950; 95% CI: 0.923-0.977; P<0.001); and (5) DC (HR: 0.409; 95% CI: 0.362-0.977; P=0.595) (Table 2; Figure 1). The gene discussed is TNNI3; the disease is diabetes mellitus.