In the training cohort, hypertension (P=0.133), diabetes (P=0.017), nLF/nHF (P=0.021), DC (P=0.040), cTnI (P=0.031), post-PCI QFR of target vessel (P<0.001) and the sum of QFR in three vessels (P<0.001) were potential correlated with increased risk of MACEs according to the result of univariate Cox regression analysis (Table 2). This evidence concerns the gene TNNI3 and diabetes mellitus.