MMP1 and renal cell carcinoma: We found that MMP1 expression was significantly higher in RCC tissues than in normal kidney tissues (Figure 3B) and that higher MMP1 expression was associated with a higher tumor stage (P = 0.0473) (Figure 3C) and tumor grade (P = 0.0008) (Figure 3D) and poorer overall 10-year survival (P = 0.017) (Figure 3E).