One NTRK fusion-positive CRC patient’s tumor was MSI-H, TMB-H (91.6 mut/Mb) and PD-L1 IHC positive (CPS score = 80%) with a POLD1 co-mutation, and another case with metastatic small intestine cancer was also MSI-H and TMB-H (80 mut/Mb) with a POLD1 co-mutation (Supplementary Tables S2, S3). Here, POLD1 is linked to small intestine cancer.