An opposite trend was observed in CRC tumors where NTRK-positive tumors trended toward higher TMB scores (7.8 vs. 6.2 mutations/Mb, P = 0.06) and had significantly higher PD-L1 IHC scores (20 vs. 0 CPS, P < 0.0001) (Figures 6A,B). This evidence concerns the gene CD274 and colorectal carcinoma.