This contradicts Westphal et al.,20 be related to progressive dysfunction of the hypothalamic-pituitary axis after BD and, in 80% of cases, the development of diabetes insipidus, which results in a decline in circulating antidiuretic hormone.30 The polyuria resulting from this endocrine/metabolic change can lead to serious electrolyte disorders, such as hypernatremia, hypokalemia, hypocalcemia, hypophosphatemia, and hypomagnesemia.14 In a study by Vasconcelos et al. with possible human donors, 47.7% had hypernatremia, similar to the values obtained in this study.31 This evidence concerns the gene AVP and diabetes insipidus.