Alteration of adiponectin before the onset of hyperglycemia and dyslipidemia may be explained by the fact that, in spite of elevated expression of mRNA for adiponectin, it has been observed that there is a decrease in receptor expression and also deactivation of the PPAR-α/AMPK (AMP-activated protein kinase and peroxisome-activated receptor-α) pathway. This evidence concerns the gene PPARA and metabolic syndrome.