TAMs secrete multiple factors that can support tumour growth and aid the epithelial- mesenchymal transition (EMT) of tumour cells, such as IL-1β, IL-16, and TGF-β, as well as extracellular matrix (ECM)-degrading proteins, such as cathepsins, matrix metalloproteinases (MMP7, MMP2, and MMP9), and serine proteases that enable tumour cell migration, via ECM remodelling [52–54]. This evidence concerns the gene CTSS and neoplasm.