In addition, trabectedin (a DNA alkylating agent), originally approved/developed as an anti-proliferative agent for soft tissue sarcoma and relapsed ovarian cancer was reported to induce apoptosis of intra-tumoural monocytes and macrophages through caspase 8 activation via a TNF-related apoptosis-inducing ligand (TRAIL)-dependent mechanism [66]. The gene discussed is TNFSF10; the disease is soft tissue sarcoma.