In this study, we report that CD73+CD8+ T cells, a subpopulation found in the peripheral blood of DLBCL patients, exhibit enhanced effector functions, characterized by lower expression of inhibitory receptors (PD-1, TIM-3, TIGIT, 2B4) and higher levels of activating markers (CD69, CD25). Here, CD69 is linked to diffuse large B-cell lymphoma.