Finally, we co-cultured CD73+CD8+ T cells or CD73−CD8+ T cells with DLBCL cell lines (SU-DHL-6, OCI-Ly3) in vitro and found more apoptosis in DLBCL cell lines co-cultured with CD73+CD8+ T cells. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.