Besides, genes from molecular pathways of autophagy (ULK/ATG complex), drug efflux (ABC transporters), mitochondrial activity (V‐ATP synthase), hypoxia (HIF1A), and PI3K/mTOR (PIK3CA, CASTOR1, and DEPTOR) were upregulated in resistant laryngeal cancer cells. Here, DEPTOR is linked to laryngeal carcinoma.