Although IL-10 is known as a potent anti-inflammatory cytokine (Mollazadeh et al., 2019; Saraiva and O’Garra, 2010) and has been emphasized in Breg cell-related therapy, excessive IL-10 levels may lead to immune disorders and increase the risk of autoimmune diseases by disrupting the immune balance and regulating the activation of immune cells. This evidence concerns the gene IL10 and immune system disorder.