IL10 and autoimmune disease: Although IL-10 is known as a potent anti-inflammatory cytokine (Mollazadeh et al., 2019; Saraiva and O’Garra, 2010) and has been emphasized in Breg cell-related therapy, excessive IL-10 levels may lead to immune disorders and increase the risk of autoimmune diseases by disrupting the immune balance and regulating the activation of immune cells.