CD8A and neoplasm: We summarize several key features related to the efficacy of ICIs in TDLNs: 1) dynamic changes in stem-like T cells and T cells: there exists a subset of stem-like CD8+ T cells in TDLNs, which, once generated in TDLNs, can proliferate and differentiate independently of sustained antigen stimulation, crucial for long-term anti-tumor immunity.