In TDLNs, extremely large numbers of Tnaive scan specialized APC-presented TAAs, in which different types of CD4+ T cells support the antitumor immune response, which is not only an adjuvant role of CD4+ T cell subsets to CD8+ T cell, but also acts as an antitumor agent by directly attacking tumor cells and their stromal support. The gene discussed is CD8A; the disease is neoplasm.