CPXM1 and type 2 diabetes mellitus: We identified risk-increasing causal effects of CPXM1 on T2D risk in the plasma pQTL MR analysis (OR=1.05, q-value=1.45×10−2) and replicated in two independent cohorts from EUR, as well as in the eQTL MR analysis in skeletal muscle (OR=1.07, q-value=1.23×10−4) and subcutaneous adipose tissue (OR=1.07, q-value=5.69×10−5) (Supplemental Figure 5).