Two nonsynonymous coding variants in this gene have been reported to be associated with a decreased risk of T2D in the German population32, as well as rs7872702, a variant upstream PTGES2, in the latest T2DGGI AFR GWAS meta-analysis2 (OR = 0.96, p-value = 5.97×10−7). The gene discussed is PTGES2; the disease is type 2 diabetes mellitus.