Of the 81 genes with significant causal effects on T2D risk in the meta-analysis, evidence of ancestry-related heterogeneity, as determined by a nominal significant Cochran’s Q statistic, was found for only one gene, KLHL42 (Cochran’s p-value = 3.96×10−2), and for none of the proteins. The gene discussed is KLHL42; the disease is type 2 diabetes mellitus.