BORCS5 and Parkinson disease: The genes encoding Cathepsin B and glucocerebrosidase, whose activity is reduced by BORCS5 mutations, are established risk factors for PD.35–38Additionally, we observed that the axonal spheroids in one of the BORCS5-mutant cases (F-VII:1) with NAD displayed strong staining for α-synuclein, the most abundant protein found in Lewy bodies (LBs).