IL1RN and Familial prostate cancer: Though we do not fully understand the mechanisms via which these SNPs may be causal of prostate cancer, it is notable that two of the top SNPs are both involved in the same inflammatory pathway (the IL1 pathway) with the protein encoded by IL1RN (IL1-RA) being an antagonist for IL1-R1 which is also a receptor for the key gout cytokine IL-1β.