Consistent with this, HSPB8 mutations causing hereditary distal motor neuropathy have been shown to impair the delivery of autophagosomes to the lysosomal compartment (Kwok et al., 2011), whereas upon HSPB8 can efficiently promote the autophagosome-lysosome heterotypic fusion in neurons in a rat experimental model of diabetes (Li et al., 2017). This evidence concerns the gene HSPB8 and Motor axonal neuropathy.