HSPB8 functions as a chaperone interacting with the Bcl-2 associated athanogene 3 (BAG3) during autophagy and promotes the removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS) and other motor neuron diseases, such as TDP-43 (Crippa et al., 2010; Crippa et al., 2016). Here, BAG3 is linked to motor neuron disorder.