In addition, most mutations in HSPB1 can cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy (Evgrafov et al., 2004; Echaniz-Laguna et al., 2017) and sporadic amyotrophic lateral sclerosis (ALS) (Capponi et al., 2016). Here, HSPB1 is linked to amyotrophic lateral sclerosis.