WEE1 and cancer: For that reason, novel hybrid anticancer agents (conjugates)were developed for treating cancer more successfully.34 Such a strategy has been known for a long time and is usedgenerally quite often, also in our team.35−37 Based on amolecular hybridization strategy, the required conjugates were designed,targeting multiple protein kinases in cancer cells.34 The studied hybrid agents combined purine and isatin (alsoknown as tribulin; 1H-indole-2,3-dione) moietiesin their structures together with 4-aminobenzohydrazideand hydrazine as different linkers.