EIF4E and cancer: Dysregulation of the cap-dependenttranslation is linked to the development and progression of cancer.28 Once the phosphorylated subunit eIF4E, furtheridentified as (p)-eIF4E, binds to the cap structureof mRNA, it supports a nonstop translation process.28 In this regard, a series of the new GMP analogues weresynthesized to target eIF4E and suppress its binding to the mRNA capstructure (8a–8f; Figure 8).28 The compounds of this series were tested in three types of cancercell lines: Caco-2, HepG2, MCF7, and normal kidney cells (Vero cells)(Table 7).