CT (Computed Tomography): Detects structural abnormalities and excludes other causes of cognitive decline, such as tumors or significant brain atrophy.MRI (Magnetic Resonance Imaging): High-resolution imaging to detect hippocampal atrophy, a hallmark of AD.PET (Positron Emission Tomography): depicts molecular /functional data, e.g., glucose metabolism or amyloid and tau deposits.Each modality, i.e., CT, MRI and PET provides unique understandings but poses challenges for integration because of different spatial/temporal resolutions and biological targets (Zhang Y.-D. et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.