As C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are widely recommended as PJI diagnostic markers in various guidelines (Della Valle et al., 2011; Parvizi and Gehrke, 2014; Tande and Patel, 2014; Parvizi et al., 2018; McNally et al., 2021), the objective of this investigation is to assess the diagnostic utility of sD-Dimer and sFDP in the context of PJI compared with CRP and ESR. The gene discussed is CRP; the disease is juvenile polyposis syndrome.