RAN and early-onset autosomal dominant Alzheimer disease: In the Eg.P29/3HA-pCDNA3.0 group, the enriched biological functions were cadherin binding, ATPase activity, and Ran GTPase binding (Figure 1G), and the enriched KEGG pathways were Alzheimer’s disease, protein processing in endoplasmic reticulum, RNA transport, and spinocerebellar ataxia (Figure 1H).