The derived thresholds—T1 ratio > 0.95, RV-LASIns/mid < −23.1%, RV-LASLVapex/peri < −20.2%, RV-LASLVapex/mid < −21.5%, and RVESRI >1.34—may serve as robust discriminators of RV impairment for anti-MDA5 Ab+ DM patients in clinical practice. Here, IFIH1 is linked to diabetes mellitus.