Moreover, non-foamy macrophages not only have higher expression of genes involved in pro-inflammatory responses such as IL-1β, Tnf, Ccl2, Cx3cr1, Nlrp3, and TREM1 (7, 64) but also atherosclerosis-associated genes such as Egr1, Nlrp3, Cebpb (56, 121, 122). The gene discussed is NLRP3; the disease is atherosclerosis.