After 48 h of excess copper (1 × 10−9∼1 × 10−7 M) treatment, a combination of copper and IDH2R140Q mutation robustly inhibited the viability of leukemia cells compared to wild type THP-1 and THP-1 with wild type IDH2 overexpression (Figures 6D and S9). This evidence concerns the gene IDH2 and leukemia.