A comparative analysis between patient-derived PBMCs and those from HDs reveals a distinct set of DEGs associated with neurologic disorders, including SNHG5, SLC35F1, RASGEF1B, SLC26A3, LINGO1, SLC27A4, and FAM118A. These findings offer novel insights into the prediction of neurologic changes induced by WD. The gene discussed is SLC26A3; the disease is Wilson disease.