HLA-A and chronic myelogenous leukemia, BCR-ABL1 positive: The downregulation of HLA-A, B, and C and HLA-DR, DP, and DQ was observed in monocyte-like cell line THP-1 totally (Figure S6B), and similar results can be gotten from chronic myelogenous leukemia (CML) cell line K562 in less than 48 h after treatment with ES with or without copper (Figure 4Ai).