VHL and renal cell carcinoma: In 786-O VHL-/- cells treated with SKPin C1, the EB1 comets became dim rapidly within an hour, while the compound did not affect the EB1 comets until the end of the tracking experiment (105 min) in 786-O wtVHLoe cells (Fig. 6A), demonstrating that SKPin C1 rapidly shut down microtubule growth in VHL-deficient RCC cells.