The FMRP-targeting PROTAC degrader sc1-VHLL, delivered via lipid nanoparticles, specifically ubiquitinates FMRP in tumor cells, remodeling the tumor microenvironment by enhancing CD8+ T cell infiltration and reducing Treg populations in CT26-bearing mice, thereby converting immunologically "cold" tumors to "hot" lesions 185. The gene discussed is VHLL; the disease is neoplasm.