Besides upregulating GPT2 expression, LncRNA UCA1 also regulates inosine monophosphate dehydrogenase 1 and 2 (IMPDH1/2) expression via TWIST1, which alters metabolite levels and promotes guanine nucleotide de novo synthesis, thereby reprogramming the metabolism of bladder cancer cells 147. Here, IMPDH1 is linked to urinary bladder carcinoma.