MDM4 and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), SRSF10 suppresses MDM4 exon skipping to downregulate p53 protein levels, concurrently reducing CD8+ T-cell infiltration, inhibiting IFNα/γ signaling, and inducing HIF1α-mediated PD-L1 upregulation, collectively driving tumor progression and immune evasion 33.