IMPDH1 and urinary bladder cancer: Besides upregulating GPT2 expression, LncRNA UCA1 also regulates inosine monophosphate dehydrogenase 1 and 2 (IMPDH1/2) expression via TWIST1, which alters metabolite levels and promotes guanine nucleotide de novo synthesis, thereby reprogramming the metabolism of bladder cancer cells 147.