ARHGEF15 and neoplasm: The expression of key genes, including ARHGEF15, KIF26A, DNAJC22, GJA3, and SCN8A, was significantly upregulated in the mutp53 group, indicating enhanced tumor proliferation, invasion, migration, and antiapoptotic activities; conversely, the downregulation of genes such as PPP1R9A, DLGAP1, GABRE, CASD1, and LINGO2 in the same group suggested disruptions in synaptic signaling, cellular architecture, and apoptosis in tumors expressing mutp53 (Figure 3D andSupplementary Table 6).