The activation of hallmark pathways, including Hedgehog signaling, unfolded protein response, EMT, hypoxia, TGFβ signaling, cholesterol homeostasis, and the TNFA signaling pathway NFKB, mirrors the highly dynamic and adaptive of tumor cells with intensive SRGN expression in their tumorigenic niche. The gene discussed is TGFB1; the disease is neoplasm.