As the tumor progressed, the proportion of malignant cells with high expression of SRGN gradually increased in the G1 and G2M phases (Figure 5A), validated in an external cohort (Supplementary Figure 6), which might be related to SRGN's involvement in regulating the energy and substances of these two stages of the EMT process to support DNA replication and cell division. Here, SRGN is linked to neoplasm.