MAPT and Alzheimer disease: Genome-wide miRNA screening in Drosophila identified inhibitors of tau-mediated AD pathology, pinpointing the miR-9 family as potent inhibitors of human tau overexpression, and overexpression of CG11070, a target gene of Drosophila miR-9a, or its mammalian homolog UBE4B, increased tau ubiquitination and degradation, leading to reduced total and phosphorylated tau levels, thereby suggesting a potential innovative therapeutic strategy for AD114.