In our LPS-induced sepsis model, the CL-treated mice reconstituted with SLC25A33-silenced BMDMs exhibited a higher survival rate and decreased secretion of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, relative to mice reconstituted with vehicle-treated BMDMs (Fig. 6D-E and S5C-D). This evidence concerns the gene SLC25A33 and Sepsis.