MAPT and Alzheimer disease: 2021; Insel et al. 2020; Palmqvist et al. 2017). Both postmortem and in vivo studies have demonstrated a spatial correlation between iron accumulation and amyloid or tau aggregation (Everett et al. 2014; Sayre et al. 2000), suggesting that iron accumulation may be involved in the pathogenesis of early AD by accumulating in senile plaques and neurofibrillary tangles, where oxidative stress induced by a redox imbalance can cause neuronal degeneration (Everett et al. 2014; M. A. Smith et al. 2010).