2022). Cytokines bind to their receptors and activate JAK kinases, leading to their phosphorylation and dimerization, and phosphorylated JAK activates STAT to induce its phosphorylation. Phosphorylated STAT enters the nucleus and regulates the expression of genes (Bastian et al. 2019; Huang et al. 2022; O'Shea et al. 2015). The JAK‐STAT signaling pathway is involved in many autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and SLE (Banerjee et al. 2017). This evidence concerns the gene SOAT1 and ulcerative colitis.