First, as a retrospective study based on the MIMIC-IV database, the substantial missing data for several key variables, such as contrast agent dosage, infection markers (eg, procalcitonin and C-reactive protein), and cardiac biomarkers, may have led to the loss of potentially valuable predictive information related to contrast-induced nephropathy, AMI, and sepsis-associated AKI. This evidence concerns the gene CRP and acute kidney injury.