Vascular development is indispensable for embryonic growth, wound healing, and the female reproductive cycle.1 However, when VEGF signaling is dysregulated, various disorders such as cancer, diabetic retinopathy (DR, diabetes-induced retinal vascular disorder), and age-related macular degeneration (AMD, retinal disease characterized by macular degeneration) develop.3 Extensive research on VEGF-VEGFR signaling has advanced the development of therapeutic inhibitors that disrupt pathological angiogenesis. The gene discussed is VEGFA; the disease is age-related macular degeneration.