This maturation, regulated by extracellular proteases such as PC and plasmin, modulates receptor specificity and bioactivity.65,67 VEGF-D differs from VEGF-C in expression patterns, predominantly found in the lungs, heart, skeletal muscle, and intestines.67,68 VEGF-C and VEGF-D regulate lymphangiogenesis via VEGFR3 and contribute to angiogenesis through VEGFR2 under specific conditions.69,70 This dual functionality highlights its role in coordinating vascular and lymphatic growth, particularly in cancer metastasis, underscoring its significance in tissue homeostasis and disease progression. This evidence concerns the gene PLG and cancer.