In contrast, Ang2 acts as a context-dependent modulator, often destabilizing vessels under conditions such as inflammation, ischemia, and tumor angiogenesis.193,194 By increasing vessel permeability, Ang2 sensitizes ECs to VEGF, enhancing angiogenic sprouting.195,196 Notably, VEGF signaling upregulates Ang2, creating a feedback loop where VEGF-induced Ang2 expression counteracts TIE2 stabilization by Ang1.197. The gene discussed is VEGFA; the disease is neoplasm.