VEGFA and eye disorder: In DR, MALAT1 supported EC growth and migration via the YAP1/miR-200b-3p/VEGF-A pathway.235 In retinopathy of prematurity (ROP, eye disorder of abnormal retinal blood vessel development in premature infants), MALAT1 inhibition with siRNA reduced retinal neovascularization and lowered VEGF and inflammatory markers, highlighting its role in abnormal retinal vessel development.236 Together, MEG3 and MALAT1 illustrate the diverse and opposing roles of lncRNAs in angiogenesis and vascular pathology.