Its pathogenesis is associated with chronic inflammation, lipid accumulation, oxidative stress, and ECM dysfunction.520 In neovascular (wet) AMD (nAMD), immune cell recruitment to the macula leads to the release of pro-inflammatory and pro-angiogenic cytokines, including VEGF, driving pathological neovascularization. The gene discussed is VEGFA; the disease is age-related macular degeneration.