Epigenetic silencing of miR-126 increases VEGF-A levels, enhancing neovascularization and metastasis.222 Conversely, miR-16 directly targets VEGF-A in cancers such as multiple myeloma and lung cancer, reducing tumor growth and angiogenesis.223,224 Similarly, miR-205 is a key regulator in various cancers, affecting angiogenesis, metastasis, and chemoresistance. Here, VEGFA is linked to plasma cell myeloma.