VASH1 and cancer: Vasohibin (VASH), identified as a VEGF-inducible gene in ECs, acts as a negative regulator of angiogenesis.266,267 VASH inhibits EC migration, proliferation, and network formation, specifically targeting ECs without affecting other cell types.266,268 Its expression is downregulated by hypoxia and inflammatory cytokines, such as TNF-α, potentially impairing its anti-angiogenic activity in conditions such as cancer.