SH2D2A and retinal disorder: Y951 (Y949 in mice) phosphorylation recruits TSAd, essential for vascular permeability by destabilizing VE-cad via the VEGFR2-TSAd-SRC complex.169 Mice with the Y949 mutation (Flk1Y949F/Y949F) show reduced VEGFA-induced vascular leakage and metastasis, offering therapeutic potential for conditions such as oxygen-induced retinopathy.171