Tumors often induce high expression levels of VEGF-C, which, through the VEGF-C/VEGFR3/NRP2 axis, promotes the proliferation, migration, and survival of LECs.191,192 This mechanism is especially relevant in lymphatic metastasis, as lymphatic vessels serve as conduits for tumor cells to reach and colonize distant sites. Here, NRP2 is linked to neoplasm.