CD274 and hepatocellular carcinoma: Knockdown of METTL3 reduced VEGF-A translation and angiogenesis, demonstrating the therapeutic potential of targeting the m6A/VEGF-A axis in lung cancer.215 In addition, Wilms tumor 1-associated protein (WTAP), a key component of the m6A methyltransferase complex, promotes colorectal cancer progression by enhancing VEGF-A through m6A modification mediated by YTHDC1.216 Interestingly, YTHDF2, an m6A reader protein, promotes hepatocellular carcinoma (HCC) progression by enhancing ETV5 translation, which upregulates PD-L1 and VEGF-A, driving immune evasion and angiogenesis.