WNT5A and peripheral arterial disease: However, VEGF-A165b, known for its anti-angiogenic properties, is elevated in peripheral artery disease (PAD) and linked to reduced vascularization despite higher total VEGF-A levels.82 In a PAD mouse model, metabolic dysfunction and Wnt5a signaling increased VEGF-A165b, impairing angiogenesis, while its neutralization restored revascularization.