METTL3 and neoplasm: m6A modifications occur at specific adenine residues in a consensus sequence and are dynamically regulated by m6A writers (methyltransferases, such as METTL3 and METTL14), erasers (demethylases, such as FTO and ALKBH5), and readers (binding proteins, such as YTH domain family proteins).214 m6A modification in the 5′UTR of VEGF-A mRNA enhances cap-independent translation, driven by METTL3-mediated methylation and YTHDC2/eIF4GI interactions, which promotes VEGF-A expression and tumor progression.