Importantly, NRP1-mediated VEGF-A165/VEGFR2 signaling is also involved in vascular permeability, allowing for better tumor infiltration by blood vessels.188,189 NRP2, structurally similar to NRP1, is more selective in lymphangiogenesis, particularly through its interactions with VEGF-C and VEGFR3.138,190 NRP2 enhances VEGF-C binding to VEGFR3, facilitating the LEC responses required for lymphangiogenesis. This evidence concerns the gene VEGFC and neoplasm.