These published results support our finding that ANRIL, miR-181b-5p, and TMEM106B form a regulatory axis that is involved in the development of atherosclerosis in ApoE−/−ANRIL mice, although the definitive role of miR-181b-5p and TMEM106B in atherosclerosis requires characterization using transgenic mice with knockout or overexpression of the two genes. The gene discussed is CDKN2B-AS1; the disease is atherosclerosis.