In addition, as the key molecules in the downstream signaling pathway for ANRIL-induced atherosclerosis, that is, miR-181b-5p and TMEM106B, are evolutionarily highly conserved between humans and mice, we believe that ApoE−/−ANRIL mice can serve as a model for chromosome 9p21.3-associated CAD and atherosclerosis despite the noted weakness. Here, APOE is linked to coronary artery disorder.