In 2005, celiac disease, an immune-related disorder, was reported to be associated with a common variant located in intron 28 of the MYO9B gene.13 In 2022, Cipriani et al showed a possible alteration of MYO9B localization and signaling activity due to motor domain change from Tyr176His in one of two Italian families with CMT2. Here, MYO9B is linked to celiac disease.