To build on the work of Beach and colleagues, our objective was to investigate how age and APOE ε4 interact to influence the prevalence of major neuropathologies, including neuritic plaques, neurofibrillary tau, diffuse plaques, LBD, TDP-43, hippocampal sclerosis, and vascular neuropathologies (arteriolosclerosis, atherosclerosis of the circle of Willis, cerebral amyloid angiopathy (CAA), infarcts/lacunes, microinfarcts, and hemorrhages/microbleeds). This evidence concerns the gene TARDBP and arteriolosclerosis.