TARDBP and Alzheimer disease: The objective of this study was to investigate how age at death and APOE ε4 status interacted to influence the prevalence of autopsy-confirmed neuropathologies, including AD-related pathologies, LBD pathology, TDP-43, hippocampal sclerosis, and various vascular neuropathologies such as arteriolosclerosis, atherosclerosis of the circle of Willis, CAA, gross infarcts/lacunes, microinfarcts, and hemorrhages/microbleeds.