APOE and hemorrhage: In contrast, a significant positive interaction was observed for CAA (PRR: 1.00, 95% CI 0.99–1.00, p = 0.03, Fig. 2, Supplemental Table 3) and hemorrhages/microbleeds (PRR: 1.03, 95% CI 1.01–1.05, p = 0.005), indicating that the association between APOE ε4 and microbleeds strengthens at older ages.