TARDBP and Alzheimer disease: Previous NACC findings demonstrated that the prevalence of pure AD and Lewy body disease (LBD) pathology decreases with age, whereas microinfarcts, TDP-43, hippocampal sclerosis, gross infarcts, and microhemorrhages increase with age in individuals with AD neuropathologic change (intermediate or high AD neuropathological change level (ADNC)) [20].