Findings for other pathologies, including TDP-43, hippocampal sclerosis, arteriolosclerosis, atherosclerosis of the circle of Willis, CAA, gross infarcts/lacunes, and microinfarcts, did not show significant APOE ε4-by-age interactions, though age remained a significant predictor of increased burden for several of these pathologies. The gene discussed is APOE; the disease is arteriolosclerosis.