TGFB1 and cancer: It’s important to point here that trypsinogen and chymotrypsinogen have been reported to exhibit potent anti-tumor effects through various mechanisms such as: inducing redifferentiation of tumor cells, reducing cancer stem cells population via impairing their pluripotency and metastatic capacity, as well as affecting TGF-Beta pathway and protease-activated-receptors (PARs) [68].