It’s important to point here that previously Alsuwaidi and coworkers identified both ADAM6 and PRSS1 among the genes with the highest percentage of chromosomal changes in profiled B-cell precursor ALL patients, and identified PRSS1 among the potential novel players mediating ADAM6 gene homodeletion effects in pediatric ALL [20]. The gene discussed is PRSS1; the disease is acute lymphoblastic leukemia.