Whereas, in ALL patients, serum levels of ADAM6 were found to be significantly negatively correlated with LDH (r = − 0.618, p = 0.018), while serum levels of PRSS1 were found to be significantly negatively correlated with platelet count (r = − 0.370, p = 0.026). This evidence concerns the gene ADAM6 and acute lymphoblastic leukemia.