Also, in TARGET ALL samples, ADAM6 was found to be significantly upregulated in ALL tumor compared to normal (FC = 1.434, p ≤ 0.001) (Supplementary Figure S4 C), while PRSS1 was significantly downregulated in ALL tumor against normal samples (FC = −1.515, p ≤ 0.001) (Supplementary Figure S4D). Here, PRSS1 is linked to acute lymphoblastic leukemia.