Whereas, serum levels of PRSS1 were found to be significantly lower in ALL and AML patients compared to healthy controls (175.1(153.7–232.2), 177.9(145.3–206.4), and 247.5(204.3–375.3) ng/ml, p < 0.0001), respectively. The gene discussed is PRSS1; the disease is acute lymphoblastic leukemia.