It’s important to point here that an interesting report by Alsuwaidi and coworkers identified both ADAM6 and PRSS1 among the genes with the highest percentage of chromosomal changes in profiled B-cell precursor ALL patients, and identified PRSS1 among the potential novel players mediating ADAM6 gene homodeletion effects in pediatric ALL [20]. This evidence concerns the gene PRSS1 and acute lymphoblastic leukemia.