EGFR and acute leukemia: It’s noteworthy here that EGFR transactivation has been reported to play a role in acute leukemia development via activation of mitogen-activated extracellular signal-regulated kinase (MEK), Phosphatidylinositol-3-kinase (PI3 K), and Janus-activated kinase/signal transducer and activator of transcription (JAK/STAT) [50].