MALAT1 and cancer: For example, in metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which is frequently upregulated in cancer, m6 A destabilizes the hairpin stem structure of the transcript (Baspinar et al. 2020; Liu et al. 2013) and likely controls the function of MALAT1 in splicing and transcription by regulating RNA–protein interactions (Fazi and Fatica 2019; Zhou et al. 2016).