PSEN2 and Alzheimer disease: HFD might accelerate AD pathological deterioration through aggravating neuroinflammation in the hypothalamus and hippocampus [4, 5], upregulating the expression of amyloid precursor protein (App) and presenilin 2 (Psen2) genes [6], enhancing the cleavage of APP [7], and hindering Aβ degradation [8].